The primary purpose of this pilot study was to compare improvement of symptoms and role functioning in women with postpartum depression after 8 weeks of treatment with antidepressants. The study was a secondary data analysis from the preliminary data of a double blind, randomized clinical trial. The participants (n=61) were primarily Caucasian and slightly over half were married, first time mothers, and middle- to upper-middle-class. At intake, most participants were moderately to severely ill. At week one and week eight of the study, measures of symptoms and functioning were only moderately correlated. After 8 weeks of antidepressant treatment, symptoms and most measures of functional status improved; however, improvement in one dimension did not imply improvement in the other. Recommendations are given for clinical practice and further research in this area.